How to Use Your Retatrutide Pen - Step-by-Step Instructions

1

Prepare Your Pen and Needle

What you'll need:

Your prefilled Retatrutide pen
A new sterile pen needle (included with your pen)
Alcohol wipes
A sharps disposal container

First, attach the needle:

Remove the pen cap and set aside
Take a new sterile needle from the pack
Screw the needle onto the pen by turning clockwise until firmly attached
Do not overtighten - hand-tight is sufficient

2

Dial Your Dose

The pen dial shows dose units. Each unit corresponds to a specific amount:

Pen Dial Setting	Actual Dose
10 units	1mg
20 units	2mg
40 units	4mg
80 units	8mg
120 units	12mg

          Setting Your Dose:
          Turn the dose dial to your prescribed number of units
The pen will click as you turn - this is normal
Make sure the dial is set to exactly the right number
If you dial too far, you can turn back to the correct dose

        

3

Choose Your Injection Site

Best injection sites:

Belly (abdomen) - Most recommended area
Front of thighs
Back of upper arms (if someone else is injecting)

Belly Injection (Recommended):

Choose an area at least 2 inches away from your belly button
Avoid areas with scars, moles, or bruises
Pinch the fat on your belly - this creates a good injection site
Rotate injection sites to prevent skin irritation

Clean the injection site:

Use an alcohol wipe to clean the injection area
Let the area dry completely before injecting

4

Remove Needle Caps

The needle has two caps to remove:

Outer cap: Remove and keep this - you'll need it later
Inner cap: Remove and dispose of this safely

Important Safety Notes:

Be careful not to touch the needle tip
Do not bend or damage the needle
Keep the outer needle cap - you'll put it back on after injection
If you accidentally touch or bend the needle, use a new one

5

Insert the Needle and Inject

Don't Worry - It's Really Easy!

The needle is extremely small - much smaller than most needles you've seen
Very little pain - most people feel only a tiny pinch or nothing at all
The injection is quick and simple
Many people are surprised by how easy it is

Injection technique:

Pinch the fat on your belly with your non-dominant hand
Hold the pen like a pencil with your dominant hand
Insert the needle straight into the pinched skin at a 90-degree angle
Push the needle all the way in - it's very short, so it won't go too deep
Press the injection button and hold it down
Keep holding for 10 seconds - count slowly: "1 Mississippi, 2 Mississippi..." up to 10
This ensures you get the full dose

6

Remove Needle and Clean Up

After the 10-second hold:

Pull the needle straight out - don't angle it
Release the pinched skin
A tiny drop of blood is normal - gently press with a clean tissue if needed

Safely dispose of the needle:

Put the outer needle cap back on - be careful not to stick yourself
Unscrew the needle from the pen by turning counter-clockwise
Dispose of the used needle in a sharps container immediately
Put the pen cap back on your pen
Store the pen in the refrigerator

Needle Safety:

Never reuse needles - use a fresh needle for each injection
Always dispose of needles in a proper sharps container
Never throw needles in regular trash
Keep used needles away from children and pets

💡

Additional Tips for Success

          Make It Even Easier:
          Let the pen reach room temperature before injecting (take out of fridge 15-30 minutes before)
Rotate injection sites - use different areas of your belly each time
Inject at the same time each week for consistency
Keep a injection log to track dates, doses, and sites

        

Remember:

The first injection is always the most nervous - it gets much easier
The needle is designed to be as comfortable as possible
Most people find it much less painful than they expected
If you have any concerns, consult with your research supervisor